Lisicki, who owns the WTA's fastest serve, was broken six times in her 6-3, 6-2 defeat to Larsson.
"I don't get many opportunities to play in Japan, and also as a top seed I wanted to win. It's disappointing it ended this way," Japan's No.1 told The Japan Times. "I couldn't snatch it when it was a close contest late in the first set and that gave her an extra momentum, I needed to win there to stop her."
"There were no free points with my service game, all the games were tight even with those that I managed to hold and I could never get that conviction when I served."
"There's a lot more pressure when you are defending a title, and especially because I came back after I injured myself before the U.S. Open," Wickmayer said afterwards. "It was tough for me in general."
"I think in the second set I got to drop shots a bit better, but the fact that she had the chance to play many drop shots means I didn't play the right way. She's a really smart player so she did what she had to do."
Katerina Siniakova cruised in her 6-1, 6-4 win against lucky loser Antonia Lottner. Korean qualifier Su Jeong Jang, ranked No.186, scored a big upset Saisai Zheng, coming back from a set down to advance 4-6, 6-3, 6-3.