With Angelique Kerber, Roberta Vinci and Dominika Cibulkova already out over the last few days, this time it was the No.7-seeded Lisicki's time to go, though things didn't look that way early on - she won the first three games of the match. But Pavlyuchenkova came alive just in time, winning seven of the next nine games to sneak out the 56-minute first set, and eventually closing the match out, 75 63.
Pavlyuchenkova's win over the No.18-ranked Lisicki was her fourth Top 20 win of the year, her first three Top 20 wins actually being Top 10 wins too, defeating Kerber twice and Petra Kvitova once.
That wasn't the first match on the night schedule though - the comeback doubles pairing of Daniela Hantuchova and Martina Hingis was up on center court, but unfortunately they weren't able to break through against Cara Black and Vania King, falling to the Zimbabwean-American pair in two, 63 61.
Hantuchova and Hingis led 3-1 in the first set before Black and King reeled off 10 games in a row.
"It was just some deuce points here and there, so instead of being up 5-2 in the first set it became 3-4, and it all turned around there," Hingis said afterwards. "The no-ad scoring goes so fast. It's a pretty big adjustment for me. On my serve it helps sometimes, because you can put in a big serve and get a good lead, but you can also lose the momentum so fast. So that's different from when I used to play.
"I think we can play much better than we did tonight, and we showed it in the last three tournaments, so this is definitely one to cross out. So now we're just looking forward to playing at the US Open."
Hantuchova still had a lot of praise for the former World No.1, despite the tough result on Tuesday.
"I still feel like it's such a huge honor to be by her side," Hantuchova said. "She understands the game like no one else. She still has so much to show the fans and I'm so glad she's back on tour again.
"Our opponents played so well tonight, and they're both such amazing doubles players - you could hear it in their introductions, they've both won so many titles. It was just a tough match-up, really."
"We'll get over it," Hingis added. "Now we'll go to the US Open and then to the Asian tournaments."