Fast starts characterized Peschke and Srebotnik's run to the title one year ago, and they picked up from where they left off against the British wildcards, breaking twice to wrap up the opening set in under half an hour.
The second was a far closer affair as Broady and Konta, buoyed by vocal support from the home crowd, upped their level, but it was not enough to stop the No.3 seeds wrapping up a 62 64 win.
Joining them in the second round will be top seeds Liezel Huber and Lisa Raymond. After a difficult few months on the clay, in which they suffered a string of early defeats, the Americans have looked happy to be back on the grass, finishing runners-up in both Birmingham and Eastbourne.
Also advancing in straight sets were several of this year's other leading teams, including Ekaterina Makarova and Elena Vesnina, Andrea Hlavackova and Lucie Hradecka and the in-form Sara Errani and Roberta Vinci.
Despite having never been beyond the third round at Wimbledon, Errani and Vinci are arguably the favorites to lift the trophy a week on Sunday.
The Italian duo have been unstoppable in recent months, racking up seven titles, including their maiden slam at Roland Garros and on the grass of 's-Hertogenbosch. And their quick-fire 62 61 win over Eva Birnerova and Petra Cetkovska took their current win streak to 24 - the WTA's longest since 1990.
Two more people likely to have a say in who gets their hands on the trophy are Serena and Venus Williams. The sisters, playing their first event together in exactly two years, have won the Wimbledon crown on a staggering four occasions and looked as good as ever in the first round, racing past Vesna Dolonc and Olga Savchuk, 60 63.