To celebrate the historic feat, wtatennis.com is going to run down 22 of the more memorable numbers from a truly remarkable career...
346 - It has taken Serena 346 matches to win her 22 majors; Graf won her 22nd title (1999 Roland Garros) in her 303rd match
304 - Serena has the second-most Grand Slam match wins in Open Era with 304 (Martina Navratilova 306)
79 - Serena has won nearly 79% of her 28 Grand Slam finals. Her only defeats came at the 2001 US Open (to Venus Williams), 2004 Wimbledon (to Maria Sharapova), 2008 Wimbledon (to Venus Williams), 2011 US Open (to Sam Stosur), 2016 Australian Open (to Kerber) and 2016 Roland Garros (to Garbiñe Muguruza). This is the second-best winning percentage in the Open Era after Court (11-1)
64 - Remarkably, Serena has won more than a third of the 64 Grand Slams that she has contested
30 - Nine of Serena's 22 majors have come after turning 30; by winning the Wimbledon final, Williams (who is 34 years and 287 days old at the end of the tournament) also broke her own record as the oldest Open Era Grand Slam champion
20 - Since Serena lifted the 1999 US Open, 20 different women have tasted Grand Slam success
18 - The age Serena won her first Grand Slam title, at the 1999 US Open
16 - Serena has the longest winning span between majors of any woman in the Open Era at 16 years and 10 months between 1999 US Open and 2016 Wimbledon (Chris Evert, Navratilova and Graf had 12-year spans)
14 - Of her 22 Slam final victories, 14 have come in straight sets
12 - This fortnight Serena was playing her 22nd major as the No.1 seed. She has won 12 of them
9 - Nine of Serena's Grand Slam titles have come alongside current coach Patrick Mouratoglou
5 - Against Top 5-seeds at Grand Slams Serena has a better record than any other player in the Open Era (minimum five matches), winning 26 and losing just four
3 - Third time's a charm: before Saturday, the only woman in tennis history who had won the third major of a year after losing in the first two finals - as Williams has now done - was Navratilova in 1987
1 - Serena's only victory at a major as an unseeded player came at the 2007 Australian Open, when she had slipped to No.81 following a series of injuries.