In one of the first few matches of the tournament, queen of clay Justine Henin was stunned by Aravane Rezai.
Aravane Rezai screamed with joy after a come-from-behind 46 75 60 first round upset over Justine Henin.
In her first match back from a two-month elbow injury lay-off, Maria Sharapova lost to Lucie Safarova.
A fired-up Lucie Safarova celebrated her 64 63 first round upset victory over No.11 seed Maria Sharapova.
Dinara Safina suffered an early loss to Klara Zakopalova that would see her drop to No.9 on the new rankings.
World No.1 Serena Williams grabbed a ball as she prepared to serve against Vera Dushevina in her opener.
Serena Williams beat Vera Dushevina in three hours and 26 minutes, the longest match of her career.
Serena Williams rejoiced after saving match point to beat Vera Dushevina in a squeaker, 67(2) 76(5) 76(5).
Nadia Petrova put an end to Serena Williams' run in the next round, her third career win over a world No.1.
Caroline Wozniacki suffered her third straight early round exit, also losing early at Stuttgart and Rome.
A multi-exposure shot of Alona Bondarenko, who beat No.2-ranked Caroline Wozniacki - her career-best victory.
Li Na, who pledged to donate all Madrid prize money to Yushu earthquake relief, made it to the quarterfinals.
Shahar Peer's latest assault on the upper echelon took another good turn with a semifinal showing in Madrid.
Samantha Stosur lost to Venus Williams, but 21 wins in her last 25 matches make her a prime threat in Paris.
Jelena Jankovic beat Anabel Medina Garrigues in the third round for her 400th career singles match win.
Flavia Pennetta and Gisela Dulko saw their 17-match winning streak come to an end in the Madrid final.
The Williams sisters cemented a rise to the co-No.2 ranking with their second title of the year in Madrid.
Playing in her first Premier-level final, Aravane Rezai took it to Venus Williams and prevailed, 62 75.
Venus Williams congratulated Aravane Rezai after falling to the hard-hitting Frenchwoman in Sunday's final.
Aravane Rezai lifted her third and biggest Sony Ericsson WTA Tour title at the Mutua Madrilena Madrid Open.