Victoria Azarenka needed five match points but finally managed to close out Mona Barthel, 62 64.
Iveta Benesova beat Nina Bratchikova to reach her second straight Australian Open fourth round.
Agnieszka Radwanska cruised to a 62 62 victory against hard-hitting Kazakh Galina Voskoboeva.
Monica Niculescu had toughed out three-setters in her first two matches, but that run would end.
Caroline Wozniacki, ranked and seeded No.1, was too tough for Monica Niculescu, prevailing, 62 62.
Caroline Wozniacki met Monica Niculescu at the net after making the last 16. Next, Jelena Jankovic.
Julia Goerges powered into her first Grand Slam second week with a 36 63 61 win over Romina Oprandi.
Angelique Kerber made some furry Australian friends on her day off between matches on Friday.
Angelique Kerber, the No.30 seed, will play No.4 seed Maria Sharapova in the third round Saturday.
Nadia Petrova and Maria Kirilenko rolled over Klaudia Jans-Ignacik and Urszula Radwanska, 61 61.
Zheng Jie and Polona Hercog pulled off a 62 62 upset over No.16 seeds Vera Dushevina and Shahar Peer.
Kim Clijsters shone under the lights of Hisense Arena on Friday night against Daniela Hantuchova.
Daniela Hantuchova had toughed out three set wins in her first two rounds, but that run ended too.
Daniela Hantuchova suffered a 63 62 defeat to Kim Clijsters, her 10th defeat in their 11 meetings.
Kim Clijsters reached the fourth round, where she will face Li Na in a rematch of the 2011 final.