Tashkent has a strong roster of former winners, including several former Top 10 and Top 20 players.
Galina Voskoboeva recorded her best result in her sixth appearance in Tashkent - the quarterfinals.
Top seed Monica Niculescu wasn't so lucky, though, falling first round to Karin Knapp, 26 63 75.
Karin Knapp would fall in the next round however, losing to 2011 finalist Eva Birnerova, 62 62.
Bojana Jovanovski, who recently won her first WTA title in Baku, battled into the quarterfinals.
Bojana Jovanovski would succumb to Croatian teenager Donna Vekic in the quarters though, 64 64.
Alize Cornet, this week's No.3 seed, was ousted in the second round by Irina-Camelia Begu, 64 61.
Eleni Daniilidou also made the second round this week but lost out to No.6 seed Bojana Jovanovski.
No.7 seed Alexandra Panova made the quarterfinals but was edged by No.2 seed Urszula Radwanska.
Urszula Radwanska was a point from 3-0 down in the third set but beat Alexandra Panova, 57 62 76(3).
At 16 years old, Donna Vekic is the youngest player to reach a WTA semifinal since six years ago.
Irina-Camelia Begu got her first Top 10 win at the US Open and is tearing it up in Tashkent too.