One of the early matches of the day saw Kristina Mladenovic face Sam Stosur on Chatrier court.
Stosur managed to beat the French No.3, 64 63, to set up a third round clash with Jelena Jankovic.
Meanwhile, Stosur's fellow Top 10 player, Li Na, was struggling against Bethanie Mattek-Sands.
Mattek-Sands had three Top 10 wins to her name already and was seriously in the hunt for a fourth.
Mattek-Sands ended up taking out the World No.6, 57 63 62, the biggest upset of the week so far.
And the No.6-seeded Li wasn't the only one to slip up on Thursday - Dominika Cibulkova did too.
The No.16-seeded Cibulkova went out to Marina Erakovic in a see-saw three-setter, 64 26 64.
And Paula Ormaechea took out No.27 seed and 2012 French Open quarterfinalist Yaroslava Shvedova.
No.17 seed Sloane Stephens fared better though, taking out countrywoman and qualifier Vania King.
Alizé Cornet, the French No.2, cruised through her match to set up a third rounder with...
Victoria Azarenka. The No.3-seeded Azarenka dug deep to beat German teenager Annika Beck, 64 63.
Beck was the junior champion here a year ago and the No.3-ranked teenager in the world, too.
At the end of a wet Thursday it was Maria Sharapova who took Court Philippe Chatrier.
Canadian teenager Eugenie Bouchard was on the other side of the net to the No.2-seeded Sharapova.
Alas, rain stopped play one last time as Sharapova was up 62 42, and play was called for the night.