Before the two face off on Centre Court, here are 10 points to ponder...
1) Williams is attempting to equal the Open Era record of major titles.
If Williams wins, she will equal Steffi Graf's Open Era record of 22 Grand Slam titles, and move to within touching distance of Margaret Court's all-time leading tally of 24.
2) And she has a magnificent record in Grand Slam finals.
Serena has only lost six of her 27 Grand Slam finals: the 2001 US Open (to Venus Williams), 2004 Wimbledon (to Maria Sharapova), 2008 Wimbledon (to Venus Williams), 2011 US Open (to Sam Stosur), 2016 Australian Open (to Kerber) and 2016 Roland Garros (to Garbiñe Muguruza). This is the second-best winning percentage in the Open Era after Court (11-1)
4) History repeating itself?
If Kerber is looking for good omens, then she will find several by studying the 1996 Championships: Kerber and Graf overcame opponents from five different countries en route to the final; both beat their opponent in a major final earlier in the season - Graf defeated Arantxa Sánchez-Vicario at Roland Garros.
The 1996 final also pitted the No.1 and No.4 seeds against one another. Although, unfortunately for Kerber, on that occasion the No.4 seed came out second best.
5) Serena is trying to become the oldest Grand Slam champion in the Open Era. Again.
If Serena wins, she will break her own record as the oldest woman to win a Grand Slam title in the Open Era. Serena was 33 years and 285 days when she won her 21st major, at last year's Wimbledon; she will be 34 years and 283 days on Saturday.
6) Kerber displaying her bouncebackability...
Less than seven weeks ago, Kerber was crashing out in the first round of Roland Garros to Kiki Bertens. Victory over Williams in Saturday's final will see her become just the third player in the Open Era to bounce back from an opening round defeat in Paris by lifting the Venus Rosewater Dish. The other two? Serena (2012) and Venus (2001), of course.
7) Achieving the Serena-Venus double.
Kerber is bidding to become just the eighth woman to beat both Williams sisters at the same tournament. Click here to find out the identity of the magnificent seven to have achieved the feat.
8) Kerber will be back up to No.2 after Wimbledon.
Serena's semifinal victory over Elena Vesnina ended Kerber's slim hopes of overhauling her atop the rankings. However, should the German lift the title, she will trail Williams by less than 500 points.
Meanwhile, the results in south-west London have maintained the status quo atop the Road To Singapore leaderboard; Williams and Kerber will stay in the top two spots, although both are yet to secure qualification for the BNP Paribas WTA Finals Singapore presented by SC Global.
9) Kerber's unblemished record.
Kerber has not dropped a set on her way to the final. The last player to win a major without losing a set was Serena at the 2014 US Open. Marion Bartoli was the last to achieve the feat at Wimbledon, in 2013.
10) The exclusive leftie club.
Kerber is attempting to become just the fourth left-hander to be crowned Wimbledon champion in the Open Era. The other three are Ann Jones (1969) Martina Navratilova (1978, 1979, 1982-87, 1990) and Petra Kvitova (2011, 2014). The only other leftie to reach the final was 1992 runner-up Monica Seles.