CANCHA CENTRAL -- 11:00 a.m. start
 Tamara ZIDANSEK (SLO) vs. Sachia VICKERY (USA)
Not before 12:00 p.m.
[Q] Jasmine PAOLINI (ITA) vs.  Lara ARRUABARRENA (ESP)
 Magda LINETTE (POL) vs. Astra SHARMA (AUS)
[WC] Maria HERAZO GONZALEZ (COL) / Yuliana LIZARAZO (COL) vs.  Lara ARRUABARRENA (ESP) / Sara SORRIBES TORMO (ESP)
Not before 7:00 p.m.
[Q] Bibiane SCHOOFS (NED) vs. [LL] Sara ERRANI (ITA)
CANCHA 1 -- 11:00 a.m. start
Irina BARA (ROU) / Elena-Gabriela RUSE (ROU) vs. Hayley CARTER (USA) / Ena SHIBAHARA (USA)
After suitable rest
 Monique ADAMCZAK (AUS) / Jessica MOORE (AUS) vs. Ana BOGDAN (ROU) / Sachia VICKERY (USA)
Sara Errani and Bibiane Schoofs will square off for their first meeting. 2012 French Open finalist Errani made the quarterfinals in her most recent showing at the Claro Open Colsanitas, in 2017.
This will be the first meeting between Lara Arruabarrena and Jasmine Paolini. Arruabarrena is the 2012 Bogota champion and has also reached the final in the last two years. She has made at least the quarterfinals in all six of her prior appearances, and is 21-5 in main draw matches at the event in her career.
Tamara Zidansek and Sachia Vickery will face off for the first time. 5th-seeded Zidansek, the World No.67, is the highest-seeded player remaining in the singles draw.
Magda Linette and Astra Sharma will meet for the first time. Linette is a win away from making the Bogota quarterfinals for the third straight year, which would be at all three of her appearances at the event.