The No.2-seeded Kerber was the first to fall, though it wasn't to an unfamiliar face - 2010 French Open champion Francesca Schiavone did the deed, needing just 57 minutes to take Kerber out, 6-1, 6-1. Schiavone won nine games in a row at one point, going from 1-1 in the first set to 6-1, 4-0.
"For me it was a great match because I was able to play the tactics I wanted to play," Schiavone said. "I knew it would be a good opportunity for me today, and I'm happy with the way I played."
Schiavone's win over the World No.10 was her first Top 10 win since beating then-World No.6 Sam Stosur at Sydney in January 2012. The Italian had lost 17 straight against the Top 10 since then.
The next match on Centre was just as surprising, as Mona Barthel rallied from a set down to beat No.1 seed Bouchard, 4-6, 6-1, 6-2. It was the fifth Top 10 win of the German's blossoming career.
"It's always tough to play against Genie. She plays so well, you really have to play your best," Barthel said afterwards. "But today I was able to play my game, play aggressive and come into the net. At the end I had some nerves, but I'm happy I could play well to finish it. It's a great win for me."
The other seeds all survived, with No.4 seed Lucie Safarova never facing a break point to beat Kristina Mladenovic, 6-4, 6-1, No.5 seed Carla Suárez Navarro going on overdrive after the first set to beat Monica Niculescu, 4-6, 6-0, 6-2, No.6 seed Dominika Cibulkova defeating Dutch qualifier Indy De Vroome, 6-3, 3-6, 6-2, and No.8 seed Karolina Pliskova outslugging Annika Beck, 6-3, 6-3.
With the Top 2 seeds out, though, the highest seed left, and the new favorite for the title, is the No.3 seed, Andrea Petkovic, who won her second round match on Wednesday, albeit just barely - she had to fight off eight match points to beat Belgian wildcard Alison Van Uytvanck (highlights here!)
Che bravi oggi! Great team work! pic.twitter.com/4M0R50cS2f