The early goings were close, with Halep getting one break for a 3-2 lead, but the No.1-seeded Romanian reeled off nine games in a row from there to completely run away with it, 6-2, 6-0.
It ended the Slovak's six-match winning streak that started in Pattaya and continued in Dubai.
"I think she was a little bit tired because she came from Pattaya," Halep said afterwards. "Maybe I was more fresh, and I was running very well. My shots were very, very strong and very deep, too.
"I played good tennis and I'm happy I found the way to win my first match here in Dubai."
It was a good day for the other Top 8 seeds too, with No.2 seed Petra Kvitova rallying to beat Elina Svitolina, 2-6, 6-3, 6-2, No.3 seed Caroline Wozniacki surviving a 76-minute third set to get by Sam Stosur, 4-6, 6-1, 7-5, No.4 seed Ana Ivanovic winning the first eight games in a 6-0, 6-3 win over Sabine Lisicki, No.5 seed Agnieszka Radwanska outdoing Caroline Garcia, 6-3, 2-6, 6-3, No.6 seed Ekaterina Makarova beating Ukrainian qualifier Kateryna Kozlova, 6-3, 6-3, and No.7 seed Angelique Kerber fighting off five set points in the first set to beat Svetlana Kuznetsova, 7-6(9), 6-4.
Kvitova trailed Svitolina, 6-2, 1-0, and faced four points to go down 6-2, 2-0.
"I'm not sure where I was in the first set. I don't think I was on the court," Kvitova said.
"But that happens sometimes. I think I was too hectic. I really wanted to play aggressively and I made a lot of mistakes. Very easy balls, I just gave them away for free. It was tough in the end to not play as aggressive but still play aggressive, but I'm glad I kept fighting until the end and got through it.
"I knew it was going to be tough. I lost to her in Cincinnati last year."
A few of the other seeds were picked off, though, with No.9 seed and new Antwerp champion Andrea Petkovic falling to Zarina Diyas, 7-5, 6-3, No.12 seed Jelena Jankovic falling to Garbiñe Muguruza, 6-3, 6-1, and No.16 seed Peng Shuai losing to Tsvetana Pironkova in a marathon, 3-6, 6-4, 7-6(5).
Muguruza and Diyas are two of the leading WTA Rising Stars, and it was a particularly massive win for Diyas - the Kazakhstani's win over the No.10-ranked Petkovic was the second Top 10 win of her career, her first coming all the way back in 2010 at Moscow over then-World No.7 Jankovic.